The placenta epigenome–brain axis: placental epigenomic and transcriptomic responses that preprogram cognitive impairment - Genes are important, but it's expression that matters. I dunno about the "placenta-brain" axis thing though.
Human white matter myelinates faster in utero than ex utero - Heh, white matter is white because of myelination (and fibrous cell types).
A new diagnostic tool for brain disorders: extracellular vesicles derived from neuron, astrocyte, and oligodendrocyte - /u/Hopere, what's up?
Glial-derived mitochondrial signals impact neuronal proteostasis and aging - There's just a lot of "holy shit" in this one, including discovering that astrocytes have discrete channels for neurons and peripheral signalling.
Accelerated aging in mice with astrocytic redox imbalance as a consequence of SOD2 deletion - I have a love/hate relationship with stuff like this, SOD2 itself is probably irrelevant in the "big picture", it doesn't appear to be a low level part of the chain. But it does give us an idea of "what happens when redox imbalance occurs". Some distant place in the future, we'll hopefully be talking about more about biochemical interactions with classes of chemicals rather than more of this hunt and peck type of stuff.
General cognitive ability, as assessed by self-reported ACT scores, is associated with reduced emotional responding: Evidence from a Dynamic Affect Reactivity Task - Decades of MRI work am cry. "High IQ" is demonstrated by lower activation (and almost certainly has fuck all to do with brain volume or the other measures CogSci has been dry humping for awhile).
Regeneration of the cerebral cortex by direct chemical reprogramming of macrophages into neuronal cells in acute ischemic stroke - In vivo cellular reprogramming. Whoa.
Hierarchical differences in the encoding of sound and choice in the subcortical auditory system - This is the first time I've ever seen work which outright states that the entire map of functions necessary to generate behavior exists in the brain stem. One of my mini-rants is trying to get people to realize that all sensory processing starts in the brain stem, and our cortical/limbic/DCN circuitry are "enhancers" or "modifiers" of that initial salience.
Heralding a new era of oxytocinergic research: New tools, new problems? - Same problems mostly.
Retinal astrocyte morphology predicts integration of vascular and neuronal architecture - Wow a lot of cool stuff in this one. Also, I'm taking offense at the whole s100b/GFAP biomarkers are wimpy dog, even though they are almost certainly right. Crazy that they had to discard most of their cells because astrocytes overlap so much. Heh, the whole process of describing cells according to the visual impressions of someone over 100 years ago has turned into a pretty interesting roadblock for neuroscience.
Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance - Explainer Piece: Control of social hierarchy beyond neurons. Remember the whole "astrocytes are necessary for behavior" thing? Doesn't matter how complex or "simple".
Mechanical stimuli activate gene expression via a cell envelope stress sensing pathway - Hey, here's a crazy idea, what if nervous systems communicated via chemical methods and used mechanical forces to physically push those chemical products between cells in some cells using an electro-chemical "pump". And other cells do the same thing without the electro-chemical pump. But it's always mechanical. Hey, what if there were organisms that didn't use "electricity" at all, but still had predictable adaptive behavior using purely mechanical interactions? What if we could manipulate the function, differentiation, and transport of cells purely by mechanical means?
Thyroid hormone rewires cortical circuits to coordinate body-wide metabolism and exploratory drive - What if manipulating chemical elements could result in coordinated system function shifts?
What Does Physiological Mean? - I'm pretty sure 5 packs of cigarettes a day is physiological right?
The placenta epigenome–brain axis: placental epigenomic and transcriptomic responses that preprogram cognitive impairment - Genes are important, but it's expression that matters. I dunno about the "placenta-brain" axis thing though. Human white matter myelinates faster in utero than ex utero - Heh, white matter is white because of myelination (and fibrous cell types). A new diagnostic tool for brain disorders: extracellular vesicles derived from neuron, astrocyte, and oligodendrocyte - /u/Hopere, what's up? Glial-derived mitochondrial signals impact neuronal proteostasis and aging - There's just a lot of "holy shit" in this one, including discovering that astrocytes have discrete channels for neurons and peripheral signalling. Accelerated aging in mice with astrocytic redox imbalance as a consequence of SOD2 deletion - I have a love/hate relationship with stuff like this, SOD2 itself is probably irrelevant in the "big picture", it doesn't appear to be a low level part of the chain. But it does give us an idea of "what happens when redox imbalance occurs". Some distant place in the future, we'll hopefully be talking about more about biochemical interactions with classes of chemicals rather than more of this hunt and peck type of stuff. General cognitive ability, as assessed by self-reported ACT scores, is associated with reduced emotional responding: Evidence from a Dynamic Affect Reactivity Task - Decades of MRI work am cry. "High IQ" is demonstrated by lower activation (and almost certainly has fuck all to do with brain volume or the other measures CogSci has been dry humping for awhile). Regeneration of the cerebral cortex by direct chemical reprogramming of macrophages into neuronal cells in acute ischemic stroke - In vivo cellular reprogramming. Whoa. Hierarchical differences in the encoding of sound and choice in the subcortical auditory system - This is the first time I've ever seen work which outright states that the entire map of functions necessary to generate behavior exists in the brain stem. One of my mini-rants is trying to get people to realize that all sensory processing starts in the brain stem, and our cortical/limbic/DCN circuitry are "enhancers" or "modifiers" of that initial salience. Heralding a new era of oxytocinergic research: New tools, new problems? - Same problems mostly. Retinal astrocyte morphology predicts integration of vascular and neuronal architecture - Wow a lot of cool stuff in this one. Also, I'm taking offense at the whole s100b/GFAP biomarkers are wimpy dog, even though they are almost certainly right. Crazy that they had to discard most of their cells because astrocytes overlap so much. Heh, the whole process of describing cells according to the visual impressions of someone over 100 years ago has turned into a pretty interesting roadblock for neuroscience. Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance - Explainer Piece: Control of social hierarchy beyond neurons. Remember the whole "astrocytes are necessary for behavior" thing? Doesn't matter how complex or "simple". Mechanical stimuli activate gene expression via a cell envelope stress sensing pathway - Hey, here's a crazy idea, what if nervous systems communicated via chemical methods and used mechanical forces to physically push those chemical products between cells in some cells using an electro-chemical "pump". And other cells do the same thing without the electro-chemical pump. But it's always mechanical. Hey, what if there were organisms that didn't use "electricity" at all, but still had predictable adaptive behavior using purely mechanical interactions? What if we could manipulate the function, differentiation, and transport of cells purely by mechanical means? Thyroid hormone rewires cortical circuits to coordinate body-wide metabolism and exploratory drive - What if manipulating chemical elements could result in coordinated system function shifts? What Does Physiological Mean? - I'm pretty sure 5 packs of cigarettes a day is physiological right? https://ift.tt/1ZNA09m https://ift.tt/rZ1BROH
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